Zusammenfassung
Hintergrund: Der Retinal Vessel Analyzer (RVA) stellt ein neues Online-Messsystem für retinale
Gefäßdurchmesser dar. Ziel dieser Arbeit war es, die Reproduzierbarkeit der mit diesem
System ermittelbaren Werte zu evaluieren und die für den Erhalt von optimalen Resultaten
notwendigen Messbedingungen zu beschreiben. Methode: Bei 20 gesunden Probanden (M : F = 11 : 9; Durchschnittsalter: 33 ± 12 Jahre) wurden
die Durchmesser von retinalen Arterien und Venen mittels RVA bestimmt. Die Messung
wurde nach 2 Stunden und nach 2 Wochen wiederholt, und die erhaltenen Ergebnisse miteinander
verglichen. Ergebnisse: In Bezug auf die retinalen Arterien- bzw. Venendurchmesser war kein signifikanter
Unterschied zwischen den einzelnen Messzeitpunkten nachweisbar. Die Kurzzeitvariabilität
für Arteriendurchmesser betrug 1 %, der Intraklassen-Korrelationskoeffizient κ lag
bei 0,96. Die Langzeitvariabilität betrug 1,8 %, κ erhöhte sich auf 0,98. Bei den
Venendurchmessern ergab sich eine Kurzzeitvariabilität von 1 %, κ betrug 0,97. Die
Langzeitvariabilität betrug 1,5 %, κ erhöhte sich auf 0,98. Schlussfolgerung: Aufgrund der hohen Reproduzierbarkeit der Messwerte stellt das RVA-System eine geeignete
Methode zur retinalen Gefäßanalyse dar.
Abstract
Backgound: To evaluate the reproducibility of measurements with the Retinal Vessel Analyzer
(RVA) in healthy subjects and to describe which measuring conditions should be guaranteed
to obtain optimal results. Methods: The diameter of retinal arteries and veins of 20 healthy subjects (M : F = 11 : 9;
mean age: 33 ± 12 years) were measured with the RVA at baseline, after 2 hours, and
after 2 weeks. Results: No statistically significant differences in the diameter of retinal arteries and
veins between the single measurements were present. Short-term variability of arterial
diameter was 1 %, and the intraclass correlation coefficient κ was 0.96. Long-term
variability was 1.8 %, κ was 0.98. In retinal veins, a short-term variability of 1
% was calculated, with a κ of 0.97. Long-term variability was 1.5 %, with a κ of 0.98.
Conclusion: Due to the high reproducibility of its measurements, the RVA appears to be a useful
device for both analysis and follow-up of retinal vessel diameters.
Schlüsselwörter
Retinal Vessel Analyzer - Reproduzierbarkeit - Messbedingungen
Key words
Retinal Vessel Analyzer - reproducibility - measuring conditions
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Prof. Josef Flammer
Universitäts-Augenklinik Basel
Mittlere Straße 91
4012 Basel · Schweiz
Email: Josef.Flammer@unibas.ch
